Skip to content

FREE SHIPPING! On all U.S. Orders over $60 | Breaking News: Best In Skin Care Awarded to Solvaderm's ACE Ferulic See Details | Free Offers


Anti-Wrinkle Dermatological Treatment

| Submit A Review
  • Reduces Wrinkle Depth & Fine Lines
  • Boosts Collagen Production
  • Smooths, Firms, Tones & Hydrates The Skin
  • Protects Against Further Damage
Stemuderm is a multi-action, intensely hydrating treatment with clinically proven anti-aging benefits. In addition to creating skin that is smoother and firmer, for an overall rejuvenated appearance, Stemuderm protects against the development of further lines and wrinkles by naturally, and safely, relaxing the facial muscles. Learn More

Select your free sample.


You have selected . To select another option, please remove the sample from your

Free shipping on any order over $60

Free Standard Shipping is valid in the 48 contiguous United States on any order over $60 after any coupons, promotions, or discounts are applied. Eligible customers must select the Standard Shipping option during checkout in order to receive free shipping. Offer cannot be applied to expedited shipping methods.

Get all the details

Stemuderm is a professional strength, dermatological solution that combats visible signs of aging and rejuvenates your skin’s elasticity and tone. This advanced skin-firming complex contains powerful peptides and moisturizers that work together to reduce the appearance of fine lines and other surface irregularities on your skin while making it feel soft and smooth to the touch. The concentrated formula contains a growth enzyme complex that promotes skin renewal, giving your complexion a healthier, more youthful appearance and feel.

Stemuderm works on both the surface of your skin and the deeper dermal layer, giving you a rejuvenated look while also revitalizing your underlying skin structure. This potent treatment provides the following benefits:

  • Muscle Conditioning

    The Stemuderm formula includes peptides that work beneath your skin to inhibit repetitive muscle contractions and movements that stress and age your skin.
  • Firming Effects

    This product promotes stronger skin, making it appear dramatically firmer, fuller and smoother.
  • Wrinkle Reduction

    Stemuderm radically reduces the appearance of fine lines and wrinkles around the eyes, forehead, and mouth.
  • Long-Lasting Results

    The growth enzyme therapy complex in this product protects and preserves your skin, providing long-term support.
  • Moisturization

    Stemuderm contains rich moisturizers and nourishing conditioners that keep your skin hydrated and soft, making it visibly smooth and evenly-textured.

Purified Water (Aqua), Simmondsia Chinensis (Jojoba) Seed Oil, Prunus Armeniaca (Apricot) Kernel Oil, Squalane, Hyaluronic Acid, Laureth-7, C13-14 Isoparaffin, Polyacrylamide, Acetyl Hexapeptide-8, Pentapeptide-3, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Glutamyl Heptapeptide-1, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide -7, Malus Domestica Fruit Cell Culture, Phenoxyethanol, Ethylhexylglycerin.

This paraben- and perfume-free complex includes the following beneficial ingredients:

Acetyl Hexapeptide-8

Acetyl Hexapeptide-8 is a polypeptide that works somewhat similarly to Neurotoxin A without the harsh effects or need for painful injections. Comprised of naturally occurring amino acids, this polypeptide disrupts specific pathways beneath the skin to discourage muscle contractions, thereby minimizing the appearance of wrinkles and fine lines. A study of women using a cream containing acetyl heaxapeptide-8 showed an average decrease in apparent wrinkle depth of 27% after 30 days, with some women realizing a decrease between 50 and 60%.

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Also known as SYN-AKE™, this ingredient has effects somewhat similar to those of the venom from the Temple Viper snake. But, rest assured, Dipeptide Diaminobutyroyl Benzylamide Diacetate is non-toxic and completely safe. It acts to relax facial characteristics, thereby minimizing the appearance of wrinkles and reducing the repetitive muscle movements that cause them. A clinical study of this ingredient found a 52% reduction in the visibility of forehead wrinkles after 28 days and showed dramatic improvement in participants’ skin smoothness.

Acetyl Glutamyl Heptapeptide-1

Acetyl Glutamyl Heptapeptide-1 helps keep muscles in a relaxed state by interfering with proteins and pathways that cause muscle contractions beneath the skin, thereby drastically reducing the appearance of wrinkles, furrows, and lines.

Palmitoyl Oligopeptide

This peptide contains a matrikine - an amino acid compound that has multiple skin beautifying and strengthening effects. It helps improve the elasticity and strength of your skin, making it more resistant to stress and damage, and encourages extracellular matrix repair and renewal to improve skin’s appearance and tone.

Pentapeptide-3& Palmitoyl Tetrapeptide-7 (Matrixyl 3000)

Matrixyl 3000 contains two matrikines that stimulate the synthesis of elastin and hyaluronic acid, a protein and a polysaccharide, respectively, that help keep your skin full, firm, and smooth. A study of this ingredient found that women who used Matrixyl 3000 for approximately two months demonstrated a 45% decrease in the overall area occupied by deep wrinkles. The study also showed reductions in apparent wrinkle density, depth, and volume and improvements to the smoothness of the skin.

Malus Domestica Fruit Cell Culture

The growth enzyme therapy complex in this ingredient is what gives Stemuderm its restorative, long-lasting, rejuvenating effect. According to various studies, these growth enzymes, which are derived from an extremely rare apple found in Switzerland, can protect the cells found in human skin. This helps preserve your skin’s youthful appearance and slow the signs of aging. A study of this growth enzyme complex found that 100% of participants showed a noticeable reduction in apparent wrinkle depth after 28 days.

Simmondsia Chinensis (Jojoba) Seed Oil

Jojoba seed oil is a powerful emollient that is very similar to the oil naturally produced in your skin. It provides deep, non-greasy moisture that hydrates and nourishes your skin. It also improves your skin’s overall clarity and texture and reduces the appearance of fine lines.

Prunus Armeniaca (Apricot) Kernel Oil

Apricot Kernel oil is rich in fatty acids, vitamins, and antioxidants that seal in moisture and help protect your skin. This light, non-greasy compound can also firm and tone your skin while soothing irritation and swelling with its anti-inflammatory effects.


This olive oil extract hydrates your skin and helps seal in moisture, giving you a dewy complexion and providing protection from free radicals and other environmental factors that can damage your skin. A quick-absorbing moisturizer, it also helps diminish the appearance of fine lines and wrinkles and stimulates skin cell transformation.

Hyaluronic Acid

Because of its humectant properties, hyaluronic acid can hold up to 1,000 times its weight in water, making it an incredibly effective moisturizer. In addition to providing your skin with much needed hydration, Hyaluronic Acid also has a ‘plumping’ effect that reduces the appearance of fine lines, wrinkles, and other skin imperfections, giving your complexion a smoother, more even texture.

Customer Reviews

Based on 134 reviews Write a review
Directions Of Use Stemuderm

To use Stemuderm Anti-Wrinkle Dermatological Treatment, pump a small amount of the product onto your fingertips and lightly massage into your face, neck, and décolleté, using a circular motion. Focus on areas where wrinkles, fine lines, and other signs of aging are visible.

Stemuderm should be applied two times daily - in the morning and before bed - after cleansing and toning your skin. Since your skin may need some time to get used to this product, it is recommended that you start out using it every other day for the first week. After that, you may begin to use it in your daily anti-aging skincare routine.

Please note that this product uses an airless pump dispenser that will need to be 'primed' before initial use. To prime your pump, place your finger over the opening of the container and, while leaving it there, simultaneously pump the system slowly 10 to 15 times, pushing out any excess air. Repeat this procedure if your airless pump stops working at any later point.

*Disclaimer: From Solvaderm: "The FDA has not evaluated these statements and the supplement product is not intended to diagnose, treat, cure or prevent any disease. Remember to read our labels and ingredient lists carefully and follow the appropriate directions for use. If you have a specific allergy or sensitivity, do not use ingredients that may trigger a reaction. An allergy patch test is recommended if there is any doubt or history of skin reactions. Discontinue use if a reaction occurs."